Genital Nerve Stimulation (GNS) with PosStim™: A Revolution in Pelvic Disorder Treatment

Pelvic floor disorders—such as urinary incontinence, fecal incontinence, and other elimination-related dysfunctions—affect millions of individuals across all ages, genders, and backgrounds. These conditions often result from aging, trauma, or underlying medical issues that impair the normal coordination between pelvic muscles, nerves, and organs.

Among the most common pelvic dysfunctions are:

  • Urinary disorders, including urge incontinence and stress incontinence
  • Fecal dysfunctions, such as fecal incontinence

These disorders arise when the pelvic floor’s neuromuscular network fails to properly regulate voiding functions.

Modern neuromodulation therapies—which stimulate specific pelvic nerves to restore physiological function—have demonstrated encouraging outcomes. However, existing options often present drawbacks related to:

  • Inconsistent effectiveness
  • Limited comfort and compliance
  • High procedure costs
  • Concerns with long-term use or reimbursement

According to the National Association for Incontinence (1988), 64% of individuals receiving treatment for urinary incontinence report dissatisfaction with their current solution.

Enter Genital Nerve Stimulation (GNS) – A Next-Generation Solution

Genital Nerve Stimulation (GNS) is a groundbreaking approach that addresses these limitations head-on. By delivering targeted, low-frequency electrical stimulation to the dorsal genital nerve (DGN)—a branch of the pudendal nerve—GNS restores proper communication between the brain and pelvic organs.

Enabled by the NeuroGyn PosStim™ neurostimulator, this new GNS procedure offers a safe, effective, and minimally invasive treatment option for patients suffering from chronic pelvic floor disorders. It sets a new standard for durability, precision, and patient comfort in the field of pelvic neuromodulation.

1. What Is GNS?

GNS stands for Genital Nerve Stimulation. It involves sending gentle electrical impulses to the dorsal genital nerve (DGN) – a branch of the pudendal nerve that plays a key role in bladder, bowel, and sexual function. These impulses can help restore normal function by modulating the signals between the brain and the pelvic organs.

2. Scientific Background Supporting Genital Nerve Stimulation (GNS) Not to Prove Efficacy, but to Solve the Problem of Permanent Stimulation and Implantation Site

Over the past 20 years, numerous studies have clearly demonstrated the effectiveness of stimulating the dorsal genital nerve (DGN) – also known as the dorsal clitoral nerve in women or dorsal penile nerve in men – for the treatment of pelvic organ dysfunctions, particularly overactive bladder (OAB) and fecal incontinence.

For example, studies by Van der Aa et al. (2013), Worsøe et al. (2012), and El-Issaoui et al. (2024) showed that stimulation of the DGN using surface or percutaneous electrodes significantly improved symptoms in patients with OAB and idiopathic fecal incontinence. These results have been confirmed in several feasibility and pilot studies, often demonstrating reduced urinary urgency, decreased incontinence episodes, and improved bladder capacity.

A 2023 review by Posthauer et al. further emphasizes that the mechanistic basis for DGN stimulation is well-established: the DGN transmits afferent signals capable of inhibiting detrusor overactivity through central modulation at the spinal or supraspinal level, similar to pudendal and sacral neuromodulation—but with a more targeted and localized effect.

Therefore, the question is no longer whether GNS works, that has been scientifically proven. Rather, the real challenge has been:

  • How can we ensure permanent and reproducible stimulation of the genital nerves?
  • And critically: where and how should a neurostimulator be implanted?

Until now, most stimulation protocols have relied on external TENS devices or temporary percutaneous electrodes, which are unsuitable for long-term use due to skin irritation, hygiene concerns, and poor long-term compliance.

The breakthrough innovation came with the development of the patented GNS procedure (NeuroGyn AG), which for the first time enables:

  • Apermanent, subcutaneous implantation of the stimulation lead on the DGN.
  • Aprecise anatomical approach, accessing the nerve just behind the pubic bone (sub/retropubic), where it runs only millimeters beneath the skin, both in women and men.
  • Aminiature, low-profile neurostimulator implanted directly behind the symphysis pubis, completely avoiding the need to place a device in the vulva or scrotum.

This minimally invasive „two-pass technique“, described by Possover (2023), allows for precise electrode placement under local anesthesia in less than 10 minutes, with reproducible outcomes and extremely low procedural risks. This technique solves the long-standing barrier of how to make DGN stimulation viable for chronic neuromodulation.

In contrast, sacral or pudendal neuromodulation techniques (e.g., InterStim, Axonics) require advanced surgical expertise, fluoroscopy, and implantations near the sacral foramina, often under general anesthesia, with significantly higher cost and complexity.

In summary, the scientific literature already supports the efficacy of genital nerve stimulation for pelvic dysfunctions. The true innovation of the GNS procedure lies in providing a practical, durable, and patient-friendly solution to what was, until now, a purely technical and anatomical challenge: how and where to implant a permanent stimulator on such a superficial, sensitive nerve.

Key references

Key references
Sources:

 „Dorsal Genital Nerve Stimulation for the Treatment of Overactive“

„Dorsal Genital Nerve stimulation in patients with overactive bladder“

 „Sacral Neuromodulation – StatPearls – NCBI Bookshelf“

3. Advantages of the GNS therapy comparing to SNM

3.1. Non-Invasive Testing Before Implantation (Trial Phase)

Before committing to surgery, patients can test the effectiveness of GNS using a simple external TENS (Transcutaneous Electrical Nerve Stimulation) device with two adhesive electrodes placed on the skin near the vulva or the penis. This helps evaluate whether stimulation relieves symptoms – without time pressure for decision or risk. The only limitation: TENS can’t be used long-term due to skin irritation.

3.2. Minimally Invasive Final Implantation

The GNS procedure is simple, reproducible, and Minimally Invasive (no dissection required, small incisions, very small neurostimulator with high and rechargeable batterie capacity).

GNS can be performed under local anesthesia in less than 10 minutes. The technique is based on the same surgical approach used in the widely practiced TVT (tension-free vaginal tape) procedure for incontinence, making it familiar to most gynecologic surgeons. Only two incisions from <1mm at the genital area are required and a 1cm above the pubic bone for implantation of the neurostimulator.

An anatomical study published by Prof. Possover confirmed that the genital nerves in both men and women follow a highly predictable path, allowing for precise and reliable electrode placement without the need for X-ray guidance or nerve monitoring during surgery (Possover M., J Minim Invasive Gynecol. 2023;30(6):480–485).

It is important to note that the TVT procedure is actually more invasive than sacral neuromodulation. The passage of the tape occurs near the urethra, bladder, and retropubic vessels, exposing patients to potential risks such as hemorrhage, hematoma, and urethral or bladder injury. In contrast to the TVT, the retropubic approach used in GNS is performed approximately 2 cm lateral to the urethra, safely distant from both the urethra and the perivascular plexus of Santorini, thereby significantly reducing the risk of injury, bleeding and hematoma. 

The more lateral the trajectory, the lower the risk of bladder injury. Nonetheless, to ensure absolute safety, a cystoscopy is systematically performed after passing the applicator behind the pubic symphysis, to confirm that the bladder has not been perforated. If accidental entry into the bladder is detected, the applicator can simply be withdrawn and reinserted, either by adjusting the trajectory along the dorsal edge of the symphysis or by performing the implantation on the contralateral side, as genital nerves are present on both the left and right sides.

 

ParameterSNMGNS
Surgical Trial PhaseYesNo (skin electrodes / TENS device)
Duration of Trial Phase2–3 weeksAs long as necessary
Final Implantation60–90 min< 10 min
AnesthesiaLocal or GeneralLocal
SettingStationary (inpatient)Outpatient
Risk of Urethra LesionNoNo
Risk of Bladder InjuryNoVery low (far from bladder)
Risk of Intestinal InjuryLow–MediumNo
Risk for HemorrhageVery lowVery low
Risk of InfectionLow–MediumLow
Accessibility for Gynecologists0.35%Almost 100%
Needs X-ray / FluoroscopyYesNo
Lead Dislocation RiskYesNo
Risk for Cable BreakageYesNo (protected by the pubic bone)
Requires Technician in ORYesNo
Requires Post-Implantation ProgrammingYesNo
CostsHigh> 60% cost reduction

3.3. Durable and Technically Secure

The passage of the electrode cable under and then behind the pubic symphysis protects it from any external impact – significantly reducing the risk of cable rupture.

The NeuroGyn neurostimulator has been designed in such a way that its migration behind or above the pubic symphysis is virtually impossible.

Due to its specific shape and a maximum diameter of 1.5 cm, the supra-retropubic/subfascial implantation of „PosStim“ requires only a small skin incision of around 1.5 cm in the suprapubic area, performed as a bikini-line incision and fully concealed by standard swimwear, making the implant aesthetically “invisible”.

Thanks to a patented neurostimulator developed by NeuroGyn AG, the electrode cable and neurostimulator are permanently pre-connected during manufacturing and delivered in sterile packaging.

PosStimTM comes pre-programmed with electrode lead pre-assembled “out-of-the-box”

This allows the surgeon to test the complete neuroprosthesis before implantation, ensuring:

  • System integrity is guaranteed before opening the packaging and before starting with the procedure
  • Clear responsibility in case of device failure:
    If a technical defect is identified before the sterile packaging is opened, NeuroGyn AG assumes full responsibility for device replacement and associated costs.
    If the defect is detected after the package is opened, responsibility lies with the operator or the person who opened the packaging. In this case, the device can still be replaced before the start of the surgery, avoiding delays during the procedure, which is crucial when operating under local anesthesia.
  • Reduced surgical time – on average, 30 minutes shorter
  • Lower risk of infection and connection errors
  • No need for surgical screws or additional tools for connecting the cable to the neurostimulator
  • No technical staff required in the operating room to verify connection and functionality, making the procedure highly scalable and surgeon-independent.

4. The Simplicity and Accessibility of the GNS Procedure for Gynecologists - A Paradigm Shift in Neuromodulation

The Tension-Free Vaginal Tape (TVT) procedure is one of the most frequently performed interventions in gynecology, with more than 10 million procedures carried out worldwide since its introduction in the 1990s (Nilsson et al., 2013). Its minimally invasive nature and high success rates have made it a standard procedure in the treatment of stress urinary incontinence, commonly performed even in small gynecological practices.

The Genital Nerve Stimulation (GNS) procedure builds on this legacy of simplicity and effectiveness. Designed to be just as straightforward – if not easier – than the TVT, GNS can be performed by any trained gynecologist without requiring a steep learning curve. The technique is so intuitive that it can be reliably reproduced after watching a detailed instructional video. No technical expertise beyond routine gynecological skills is required.

Technical Innovation of the GNS Procedure: Retrograde Electrode Insertion Enabled by a Patented Tunneling System

No specialized surgical instruments are required for the GNS procedure – except for the dedicated tunneling applicator developed, tested (TRL 8–9), and patented by NeuroGyn. This applicator is specifically designed for gynecologists, requiring only standard procedural skills.

Like in the sling-TVT procedure, the applicator is inserted through a small skin incision at the level of the external genitalia, tunneled underneath and behind the pubic symphysis, and exits the body again above the symphysis through a second small incision. After withdrawing the guiding drain from the applicator tip, the electrode cable – already permanently connected to the neurostimulator – can be introduced retrogradely through the tunnel created.

Retropubic passage of the patented “Neurogyn Applicator”

This innovative retrograde insertion technique is a key differentiator of the GNS system. In all other percutaneous neuromodulation techniques (e.g., standard sacral neuromodulation), the electrode must be inserted through a needle, and the inner stylet (mandrin) removed while the cable remains in place. However, in such configurations, the stimulator cannot be pre-attached to the electrode, as the mandrin would not be removable (due to the bulk of the device at the proximal end). By contrast, the GNS approach allows for pre-assembly of the entire neuroprosthesis. This enables the device to be fully pre-programmed and pre-tested for electrical function, and verified for system integrity before the sterile packaging is even opened in the operating room.

This unique tunneling and retrograde insertion approach solves the critical problem of implanting a connected neuroprosthesis in a minimally invasive, intuitive manner – dramatically simplifying the procedure and ensuring maximal safety and reliability.

This eliminates the need for intraoperative connection verification by a technician, streamlining operating room logistics and planning. Furthermore, the neurostimulator is preloaded with multiple stimulation programs based on over 20 years of clinical experience in neuromodulation. As a result, neither the surgeon nor a technician needs to perform any postoperative programming.

There is also no need for physicians to purchase or learn how to use a dedicated programmer (e.g., an iPad). Instead, patients themselves can easily manage and fine-tune their stimulation settings using a user-friendly mobile app. This enables true patient autonomy while drastically reducing follow-up appointments solely for technical adjustments. Most importantly, it frees up valuable physician time for medical rather than technical care and contributes to a significant reduction in healthcare costs over time.

In summary, GNS represents a revolution not only in its therapeutic potential but also in its ease of integration into everyday gynecological practice—safe, intuitive, and entirely independent of external technicians or programming devices.

References:
  • Nilsson, C. G., Palva, K., Aarnio, R., Morcos, E., & Falconer, C. (2013). Seventeen years‘ follow-up of the tension-free vaginal tape procedure for female stress urinary incontinence.International Urogynecology Journal, 24(8), 1265–1269.
  • Abdel-Fattah, M., Mostafa, A., & Ramsay, I. (2011). Lower urinary tract injuries after transobturator tape insertion by different routes: A large retrospective study.BJOG, 118(1), 111–116.
  • Marcelissen, T. A., et al. (2010). Management of complications associated with the tension-free vaginal tape procedure.Neurourology and Urodynamics, 29(S1), S39–S46.

5. Usability of the NeuroGyn Neurostimulator PosStim ® : A New Standard in Patient-centered Neuromodulation

The NeuroGyn neurostimulator has been specifically designed to maximize usability for both patients and clinicians, setting a new standard in ease of use, autonomy, and practical integration into everyday life. Its design is based on over two decades of neuromodulation experience and incorporates feedback from both healthcare professionals and patients.

5.1. Preprogrammed Stimulation Settings – No Need for Frequent Medical Visits

Unlike conventional systems that require physician or technician intervention to adjust stimulation settings, the NeuroGyn neurostimulator comes with multiple preloaded, clinically validated programs. These programs cover the vast majority of therapeutic needs, allowing immediate postoperative use without the need for individualized configuration. This feature eliminates repeated clinical appointments solely for technical adjustments, saving time and reducing healthcare costs. The patient can freely adjust the neuromodulation settings – not only the intensity of stimulation – according to their daily condition, bladder capacity/feeling, or specific situation they are in.

PosStim is the first neurostimulator that offers patients full therapeutic autonomy.

5.2. Patient Autonomy via Mobile App Control

The system empowers patients with full autonomy to switch between preconfigured stimulation programs based on the variability of symptoms throughout the day – for example, depending on changes in bladder irritability or pelvic pain intensity. All adjustments are made using a secure, user-friendly mobile app, eliminating the need for a separate external programming device. The interface is designed for maximum simplicity and intuitiveness and has already been evaluated in usability studies, including among elderly and cognitively impaired individuals.

5.3. Innovative Charging Concept – Seamless Integration into Daily Life

In contrast to sacral neuromodulation (SNM), where the stimulator is typically implanted in the upper buttock region and must be recharged via prolonged contact with a fixed charging pad – often requiring patients to remain seated, lying down, or standing still for extended periods – the NeuroGyn stimulator offers a highly user-friendly solution. It is implanted anteriorly, just above the pubic symphysis and below the abdomen. A specially designed belt allows for continuous charging, even while walking, making the recharging process entirely compatible with normal daily activities.

Importantly, no electrical outlet is needed during the charging phase. This gives patients the freedom to recharge their neurostimulator on the go, without interrupting work, leisure, or travel.

5. 4. Low Power Requirements – Extended Battery Life and Less Frequent Charging

Because GNS targets extremely fine nerves, such as the dorsal genital and cavernosus nerves, which nerves are much less than 1 mm in diameter, energy demands are significantly lower compared to SNM, which stimulates large sacral nerve roots (2–3 mm in diameter). As a result, the NeuroGyn neurostimulator only needs to be recharged approximately once per week, and for a much shorter duration. This further enhances patient convenience and reinforces adherence to therapy.

The PosStim has two separate batteries, each with a lifespan of at least 15 years. If one battery becomes defective, the neurostimulator can remain fully operational through the second battery.

6. Medical and Health Benefits of GNS

Unlike sacral neuromodulation (SNM), which targets specific nerve roots (S2, S3, S4), GNS stimulates both somatic and autonomic (vegetative) fibers of the pelvic nerves – simultaneously influencing bladder, bowel, and sexual functions without needing to choose one over the other.

GNS enables selective and direct stimulation of the key sensory nerve for the bladder, sexual organs, and perineal region, ensuring targeted effects without unwanted motor side effects as in SNM and pudendal nerve stimulation.

6.1. Effective for Both Urinary and Bowel Dysfunctions

Because the genital nerves connect with the same central pelvic nerve network, stimulation improves both urinary and bowel symptoms together (see references: Peters et al., Int Urogynecol J, 2013; Spinelli et al., Neurourol Urodyn, 2017).

6.2. Improves Sexual Function

Sexual dysfunctions plague both women and men, and may be life-long or acquired. Sexual dysfunction comprises a broad range of maladies, including erectile dysfunction, orgasmic dysfunction, premature ejaculation and lack of lubrication. In women, sexual dysfunction includes desire, arousal, orgasmic and sex pain disorders (dyspareunia and vaginismus). In men, sexual dysfunction of the penis is a common problem afflicting males of all ages, genders, and races. Erectile dysfunction is a serious condition for many men, and it may include a variety of problems. Some of these problems include the inability to create an erection, incomplete erections and brief erectile periods. These conditions may be associated with nervous system disorders and may be caused by aging, injury, or illness.

 

Erectile dysfunction (ED) is a highly prevalent condition affecting over 150-225 million men worldwide, with its incidence increasing significantly with age and comorbidities such as diabetes, cardiovascular disease, and pelvic surgery.

Some methods for treating erectile dysfunction include pharmaceutical treatment and electrical stimulation. Delivery of electrical stimulation to nerves running through the pelvic floor may provide an effective therapy for many patients. For example, an implantable neurostimulator may be provided to deliver electrical stimulation to the pudendal or cavernous nerve to induce an erection. The GNS procedure is the only treatment that can provide electrical stimulation of the DNP and (not “or”) the cavernous nerve to induce and sustain an erection.

Anatomical Integration of Cavernosal Nerves & Dorsal Nerve of the Penis at the Penile Root

In the male pelvis, the cavernosal nerves, branches of the inferior hypogastric (pelvic) plexus, carry parasympathetic (and some sympathetic) fibers to the erectile tissues and originate from the sacral plexus (S2–S4) (https://www.elsevier.com/resources/anatomy/nervous-system/peripheral-nervous-system/cavernous-nerves-of-penis left/25149?utm_source=chatgpt.com). In contrast, the dorsal nerve of the penis (DNP) arises from the pudendal nerve (S2–S4), exits via Alcock’s canal, and runs beneath Buck’s fascia at the penile root, accompanied closely by the deep dorsal vein (https://www.ncbi.nlm.nih.gov/books/NBK525966/?utm_source=chatgpt.com). Remarkably, at the penile root, these two nerve systems converge anatomically in close proximity, a relationship that enables simultaneous access during neuro‑stimulation procedures such as GNS (genital nerve stimulation).

Functional Roles & Stimulation Frequencies

  • The cavernosal nerves predominantly mediate the induction of erection through parasympathetic-mediated vasodilation and sustain this effect via intracavernosal pressure increases when electrically or magnetically stimulated. One key study reported full erection onset at stimulation frequencies near 60 Hz (Shafik A. Cavernous nerve stimulation through an extrapelvic subpubic approach: role in penile erection. Eur Urol. 1994;26(1):98-102. doi: 10.1159/000475351. PMID: 7925539.)
  • The DNP – Dorsal Nerve Penis, by contrast, is mainly somatosensory, conveying afferent signals essential for sexual reflexes and somatic aspects of erection maintenance. Preclinical work, including rat models, has shown that dorsal nerve stimulation modulates bulbospongiosus muscle activity and overall erectile responses (Selcuk Yucel et al. Identification of communicating branches among dorsal, perineal and cavernous nerves of penis. J. Urol. 2003; 170(1):153-8. DOI:1097/01.ju.0000072061.84121.7d)

Studies such as “US-Clinical Trial NCT05231083 – GNS for treatment for erectile dysfunctions – Prof. Possover” and others using transcutaneous or magnetic stimulation devices suggest that optimal erection outcomes may be achieved by simultaneous or frequency‑selective stimulation of both nerve types (https://clinicaltrials.gov/study/NCT05231083?aggFilters=status:not%20rec&cond=%22Impotence%22&rank=5&utm_source=chatgpt.com)

Takeaway

The anatomical proximity of the cavernosal nerves and the DNP at the penile root makes them accessible together during GNS. Each nerve responds best to specific frequency bands, cavernosal nerves for initiation (~60 Hz), and DNP for sensory reflex and maintenance. This dual‑nerve, frequency‑tuned approach is the physiological foundation of the Neurogyn neurostimulator technology.

Stimulation of the dorsal clitoris/penis and cavernosal nerves can help improve genital sensation and sexual arousal, and has shown promise in treating erectile dysfunction in men and sexual dysfunction in women.

References:

Barrese et al. (2020). Neuromodulation for Erectile Dysfunction: A Review of Current Literature. Journal of Sexual Medicine, 17(5), 899–907. 

Wespes et al. (2011). Erectile Dysfunction: European Association of Urology Guidelines European Urology, 59(5), 799–810.

Khunda et al. (2015). Sacral neuromodulation and its relevance to female sexual function: a systematic review. International Urogynecology Journal, 26(3), 321–328.  

de Groat et al. (2013). Peripheral afferent nerve pathways mediating bladder reflexes in the cat: evidence for multiple spinal pathways involved in micturition reflexes and sexual function. Journal of Physiology, 591(Pt 18), 4451–4468).

6.3. Broader Health Effects Through the Autonomic Nervous System

GNS also activates the parasympathetic nervous system, which controls many functions vital for long-term health.

How Parasympathetic Nerve Activation Promotes Blood Flow and New Vessel Growth

The parasympathetic nervous system (especially the vagus nerve) helps the body relax and recover. When it’s activated, it sends signals that widen blood vessels, a process called vasodilation.

How it works – in simple terms:

  • Special nerve endings release a chemical calledacetylcholine (ACh).
  • ACh stimulates cells in blood vessels to producenitric oxide (NO).
  • NO causes the blood vessels to relax and open up →more blood can flow through them.
  • This improves oxygen delivery, reduces blood pressure, and helps tissues heal.

 

 Vasodilation Helps Grow New Blood Vessels

This increased blood flow is the first step in forming new blood vessels, especially when tissue is damaged or healing. The process includes 1. opening existing vessels and making them more permeable, 2. Growth and movement of new vessel cells, 3.Formation of new capillaries, and 4. Stabilization and integration into the body.

References

  • StatPearls (2023) –Physiology, Vasodilation.
  • Frontiers in Neurology (2023) –Stages of Angiogenesis.
  • Nature & AHA Journals –NO and VEGF in vascular growth.
  • Frontiers in Pharmacology (2022) –Cholinergic signaling and angiogenesis in nerve injury models.
  • PubMed –Angiogenesis in inflammation and cancer.
  • https://en.wikipedia.org/wiki/Parasympathetic_nervous_system?utm_source=chatgpt.com
  • Dorschel KB et al. Physiological and pathophysiological mechanisms of the molecular and cellular biology of angiogenesis and inflammation in moyamoya angiopathy and related vascular diseases Front. Neurol., https://doi.org/10.3389/fneur.2023.661611
  • Kamiya A, Hiyama T, Fujimura A, Yoshikawa S. Sympathetic and parasympathetic innervation in cancer: therapeutic implications. Clin Auton Res. 2021 Apr;31(2):165-178. doi: 10.1007/s10286-020-00724-y. Epub 2020 Sep 14. PMID: 32926324.

This global body vasodilation & neoangiogenesis may contribute to:

  • Improved blood circulation and tissue oxygenation

Bottorff EC, Bruns TM. Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents. Int Urogynecol J. 2023 Jul;34(7):1477-1486. doi: 10.1007/s00192-022-05389-x. Epub 2022 Nov 3. PMID: 36326861; PMCID: PMC10154432.

Cakmak, Y.O., Khwaounjoo, P., Pangilinan, J. et al. Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation. Sci Rep 14, 10122 (2024). https://doi.org/10.1038/s41598-024-55165-8).

  • Better bone health and potential prevention of osteoporosis – Genital nerve stimulation (GNS) supports better bone health by activating the parasympathetic nervous system, which improves blood flow and tissue oxygenation. This enhanced circulation can help maintain bone density and may contribute to the prevention of osteoporosis, especially in patients with reduced mobility.

Tamimi A, Tamimi F, Juweid M, Al-Qudah AA, Al Masri A, Dahbour S, Al Bahou Y, Shareef A, Tamimi I. Could vagus nerve stimulation influence bone remodeling? J Musculoskelet Neuronal Interact. 2021 Jun 1;21(2):255-262. PMID: 34059570; PMCID: PMC8185259. 

Possover M (2022) Low Frequency Pelvic Nerves Stimulation: Cutaneous Vasodilation and Retoration of Bone Density in Chronic Spinal Cord Injured People. J Osteopor Phys Act. 10: 293)

  • Lower blood pressure and treatment of arterial hypertonia – GNS helps lower blood pressure by activating the parasympathetic nervous system, which promotes vasodilation and reduces vascular resistance. This effect is especially important given the high and rising global incidence of hypertension—a major risk factor for cardiovascular disease and stroke.

Cakmak, Y.O., Khwaounjoo, P., Pangilinan, J. et al. Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation. Sci Rep 14, 10122 (2024). https://doi.org/10.1038/s41598-024-55165-8

  • Mood enhancement, potentially reducing depression – GNS enhances mood and help reduce symptoms of depression by stimulating parasympathetic pathways that regulate emotional and stress responses. This neuromodulatory effect is particularly valuable as depression is one of the most common and disabling conditions worldwide, often coexisting with chronic pelvic pain.

Birendra Sharma et al. Vagus nerve stimulation ameliorates cognitive impairment caused by hypoxia. Front. Behav. Neurosci., 06 June 2025, Volume 19 – 2025. https://doi.org/10.3389/fnbeh.2025.1555229

  • Neuroprotective effects, lowering risk for dementia or Parkinson’s – By activating parasympathetic and central autonomic pathways, GNS exerts neuroprotective effects that support brain health. This could potentially lower the risk of neurodegenerative diseases such as dementia or Parkinson’s, an important benefit as these conditions are becoming increasingly prevalent in aging populations.

Ryn R. kelly et al. Effects of Neurological Disorders on Bone Health Front. Psychol., 30 November 2020. Volume 11 – 2020. https://doi.org/10.3389/fpsyg.2020.612366

https://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway?utm

  • Prevention of pressure ulcers in patients with reduced mobility – Continuous low-frequency stimulation of pelvic nerves can improve blood circulation in pressure-prone areas like the buttocks and heels. This may help prevent the development of pressure ulcers in patients with limited mobility, such as those with spinal cord injury.

Possover M. Continuous low-frequency pelvic nerve stimulation for therapy of intractable gluteal/heel pressure ulcers in persons with spinal cord injury. In press in Journal of Spinal Cord Medicine 2025.

While these systemic effects need further research, existing literature on parasympathetic activation supports their plausibility (refs: Tracey K. Nature Reviews Immunology, 2002; Ben-Menachem E. Epilepsia, 2002 on vagus nerve stimulation).

7. GNS - A New Standard?

GNS offers a scalable, cost-effective, and reproducible method that doesn’t require complex training or equipment. Just like cataract surgery revolutionized eye care, GNS could become the go-to neuromodulation procedure for gynecologists and other pelvic specialists.

In Summary, GNS represents a new era of treatment for pelvic disorders—simple, elegant, and powerful. It combines modern technology with deep anatomical insight to offer safe, fast, and patient-friendly therapy. As research continues and experience grows, GNS may become a standard solution for conditions once thought difficult to manage.

Bring the next generation of pelvic neuromodulation to your patients.

➡️  Schedule a clinical presentation or surgical training on the NeuroGyn PosStim™ procedure today.